FEB 05, 2015 06:00 AM PST

Protect Your Research: Know Your B6 Mouse

  • Technical Information Scientist, The Jackson Laboratory
      Brian has worked at The Jackson Laboratory for 20 years. He conducted research on treatment strategies for a mouse model of human enzyme deficiency. Approaches included enzyme replacement, gene therapy, and neonatal allogeneic bone marrow transplantation. He is currently a Technical Information Services Scientist. Brian's area of expertise is in modeling (and complications associated with) human type 1 and type 2 diabetes, and research with immunodeficient mice.


    Many researchers are not aware of the critical importance of genetic background of mice, including the concept of inbred substrains, and how the genetic background of substrains can impact their research. There are many different substrains of C57BL/6 mice and this presentation will not only define and explain the development of these substrains, but will also provide scientific data demonstrating how they differ in both genetics and phenotype. Participants will learn the importance of understanding what C57BL/6 substrain they are working with, how to determine what substrain they have, and use this information to ensure they are using the appropriate wild type controls to properly interpret their scientific results.

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