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APR 02, 2020 8:30 AM PDT

Rapid Discovery of Therapeutic Antibodies for SARS-CoV-2 and Other Viral Pandemics

Sponsored by: Berkeley Lights
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Product Manager, Antibody Therapeutics, Berkeley Lights, Inc.
    Biography
      Anupam Singhal earned his PhD from the University of British Columbia and has over 15 years of experience in nanotechnology and microfluidics at UBC, the University of Toronto and Stanford University. His work has been cited over 600 times and resulted in several patents for molecular disease diagnosis, antibody discovery, and development of production cell-lines for biologics. At Berkeley Lights, Anupam leads the development of next-generation platforms for the discovery and development of antibody therapeutics.

    Abstract

    Humans are susceptible to many life-threatening viruses such as HIV, influenza and Ebola. The current coronavirus pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was recognized as a pandemic by the World Health Organization (WHO) on March 11, 2020.  Rapid discovery and development of new therapeutics is therefore an absolute necessity to combat these viruses.

    B cells from exposed patients are a potential source of viral neutralizing antibodies. We will demonstrate how B Cell Antibody Discovery on the Beacon® system can be used to rapidly screen human B cells to identify anti-viral antigen-specific antibodies in under a week.  B cells can be screened from both acute and convalescent patients. Our collaborators have already leveraged the speed of our platform to discover >500 antibodies to SARS-CoV-2 in a single day.

    This workflow has the potential to enable rapid discovery of antibodies against difficult therapeutic targets such as SARS-CoV-2 and other viruses.

    Learning Objectives:

    1. Rapid discovery of antibodies against SARS-CoV-2 and other pandemic viruses
    2. Screening of B cells to identify novel therapeutic antibodies
    3. Rapid down-selection of lead candidates

     

     


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