Dr. Pardee's work at Harvard combined in vitro synthetic biology and biochemical systems with materials science to build paper-based synthetic gene networks. With this system he created a method to embed freeze-dried synthetic gene networks and their complementary cellular machinery into paper. These systems remain stable without refrigeration for more than a year, and are activated by adding water. These devices provide a new venue for synthetic biologists to operate in, and a much-needed path for the safe deployment of engineered gene circuits beyond the lab. With this technology he has developed diagnostics for the Zika virus (http://www.cell.com/fulltext/S0092-8674(16)30505-0) and as well as developed a new portable manufacturing platform for therapeutics (http://www.cell.com/fulltext/S0092-8674(16)31246-6).
Dr. Pardee's research has been published in Cell, Nature, PLoS Biology, and Genes and Development, among others.