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Reprogrammed stem cells to study psychedelic substances

Speaker
  • Head of Research Professor of Biomedical Sciences, D'Or Institute for Research and Education (IDOR) & Institute of Biomedical Sciences Federal University of Rio de Janeiro
    BIOGRAPHY

Abstract

For more than four decades, restrictions on research with psychoactive drugs have slowed progress in understanding how such substances impact brain metabolism. Besides the historical restrictions, the impacts of drug exposure in human neural cells have been compromised by limitations of adequate models. I will present the effects of the β-carboline alkaloid harmine, component of the psychoactive plant tea known as “Ayahuasca”, and 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine), found in the Sonora Desert toad, in cultures of human neural cells and brain organoids derived from induced pluripotent stem cells. Harmine increased the pool of proliferating cells, with DYRK1A (dual specificity tyrosine-phosphorylation-regulated kinase) as a target, which suggests a biological activity possibly associated with the antidepressant effects of Ayahuasca in patients with depressive disorder. Analyzing global protein expression of brain organoids exposed to 5-MeO-DMT, we found proteins broadly distributed on functional activities such as cellular protrusion formation, microtubule dynamics and cytoskeletal reorganization, which are correlated to novel dendritic spine formation. These models offer an exciting new range of opportunities to investigate the impact of psychedelics on human neural cells.           


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Reprogrammed stem cells to study psychedelic substances


Specialty

Developmental Biology

Health

Research And Development

Neural Stem Cells

Neurons

Earth Science

University

Brain Tumor

Neurogenesis

Research

Disease Modeling

Pluripotency

Geography

Asia50%

Europe50%

Registration Source

Website Visitors100%

Job Title

Medical Laboratory Technician50%

Post Doc50%

Organization

Academic Institution50%

Manufacturer - Other50%


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