Associate Professor, Department of Medicine, Division of Oncology, University of Washington, Fred Hutchinson Cancer Research CenterBiography
Dr. Mostaghel is a physician scientist specializing in androgen related mechanisms of prostate cancer progression and therapy resistance. She obtained her MD and PhD from Duke University in 2000, followed by residency training at the University of California, San Francisco, and a medical oncology fellowship at the Fred Hutchinson Cancer Research Center (FHCRC). She is currently Assistant Member in the Clinical Research Division at FHCRC, and Assistant Professor in the School of Medicine, Division of Medical Oncology, at the University of Washington in Seattle, where she specializes in the care of patients with genito-urinary malignancies. Dr. Mostaghels research focuses on translational studies addressing hormonal mechanisms of prostate cancer treatment and progression. Her recent work in prostate cancer metastases and xenograft models has identified pathways of cellular androgen transport, tumoral androgen metabolism, intracrine steroidogenesis, and expression of wild type and variant androgen receptors as potential mechanisms of disease progression, suggesting in situ analysis of these parameters can be exploited to individualize the assignment of patients to novel agents targeting these pathways.