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OCT 22, 2019 8:00 AM PDT

Role and Importance of Gastrointestinal Inflammation Markers in Diagnostics

Sponsored by: DiaSorin
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Professor of Clinical Biochemistry, King's College London, UK
    Biography
      Roy Sherwood is Professor of Clinical Biochemistry at King's College London, UK. He was until 2016 Consultant Clinical Scientist and Scientific Director of Pathology at King's College Hospital. He has a BSc in Clinical Biochemistry from Salford University, an MSC in Clinical Biochemistry from Surrey University and a DPhil from Sussex University. He has an interest in biomarkers for gastrointestinal and liver diseases in particular. He started working on fecal calprotectin in 1997 soon after it had been discovered. He is the co-author of more than 200 peer-reviewed papers, 35 reviews/book chapters and the book Liver Disease and Laboratory Medicine published by the Association of Clinical Biochemistry and Laboratory Medicine.

    Abstract

    Calprotectin is a member of the S100 family of calcium binding proteins, being a hetero dimmer of S100A8/9 and accounts for 60% of the protein in the cytoplasm of neutrophils. It is released into faeces when inflammation of the gut is present. Measurement of faecal calprotectin has been used to help differentiate inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS) for nearly 20 years since the first major study carried out at King’s College Hospital of 620 patients attending a gastroenterology outpatient clinic. Since then many studies have been carried out in both adults and children with sensitivities and specificities of more than 80% for distinguishing IBD from IBS being consistently achieved. Faecal calprotectin can be used to help determine the extent of inflammation in established IBD to gauge the need for or response to treatment. Faecal calprotectin correlates well with histological scores of inflammation in IBD and can predict both response to treatment and the risk of relapse. Recent data in patients receiving anti-TNF therapy suggests that faecal calprotectin measured after six weeks of therapy can identify those patients who will respond to this treatment (fall in calprotectin >70%). The potential use of faecal calprotectin in bowel cancer, infectious diarrhoea, intestinal transplantation and graft versus host disease after bone marrow transplantation will be presented.

    Learning Objectives:

    • Review of key Fecal Inflammatory Biomarkers and use in Clinical practice
    • Gain understanding of Calprotectins role  as a GI inflammatory biomarker
    • Understand economic impact of utilizing Calprotectin

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