APR 11, 2018 6:00 AM PDT

Sharing Data about Genomic Variants: A Clinical and Scientific Imperative

Speaker
  • Professor, School for the Future of Innovation in Society and Consortium for Science, Policy & Outcomes, Arizona State University
    Biography
      Robert Cook-Deegan is a professor, School for the Future of Innovation in Society, and Consortium for Science, Policy & Outcomes at Arizona State University. He founded and directed Duke's Center for Genome Ethics, Law & Policy 2002- 2012, and Duke-in-Washington through June 2016. Before Duke: National Academies of Science, Engineering and Medicine 1991-2002; National Center for Human Genome Research (NIH) 1989-1990; and congressional Office of Technology Assessment 1982-1988. MD, University of Colorado,1979; and BA in chemistry (magna cum laude), Harvard, 1975. Author of The Gene Wars: Science, Politics, and the Human Genome and over 250 other publications.

    Abstract

    Next-generation DNA sequencing began to enter the clinic a decade ago, a half decade after the draft human reference sequence was published.  The discovery of new genes, new variants of known genes, new genotype-phenotype correlations has produced a deluge of data, and it will take decades to figure out its clinical significance.  It will require sharing data of many kinds on many people over time, and correlation with clinical outcomes, environmental exposures, health habits, and other data.  The tasks are too large for any one institution, and yet the smooth flow of data will require cooperation and collective action: the formation of a commons.  Starting from a couple case scenarios that illustrate why data-sharing matters to clinical interpretation, we will turn to understanding the value of a commons, how it might form to enable scientific advance and better clinical care, using variants in BRCA1/2 as a case example.  We will finish with examples of policies that could make science work better and augment a learning health care system.


    Show Resources
    You May Also Like
    AUG 25, 2020 8:00 AM PDT
    C.E. CREDITS
    AUG 25, 2020 8:00 AM PDT
    DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
    JUL 22, 2020 10:00 AM PDT
    C.E. CREDITS
    JUL 22, 2020 10:00 AM PDT
    DATE: July 23, 2020 TIME: 10:00 am PDT The SARS-CoV-2 pandemic has taken a toll on many sectors of the medical community. As the pandemic took a grip on the laboratory, the need for diagnost...
    JUN 23, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 23, 2020 10:00 AM PDT
    DATE: June 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    DEC 15, 2020 10:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    DEC 15, 2020 10:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: December 15, 2020 TIME: 10:00am PST Scientists from Thermo Fisher Scientific will walk us through the world of microorganisms. They will discuss their most recent research on viruses,...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    Loading Comments...
    Show Resources
    Attendees
    • See more