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MAR 22, 2018 8:00 AM PDT

Simple and effective tools for antibody-drug conjugate screening and characterization

Speaker
  • Staff Scientist, Thermo Fisher Scientific
    Biography
      As a staff scientist at Thermo Fisher Scientific Chris leads a cross-functional team developing fluorescent probes, labeling technologies, and cell-based assays focused on immunotherapy research. Over the last twelve years he has developed more than seventy novel reagents for characterizing disease on a cellular level in areas such as innate and adaptive immunity, cell growth and proliferation, apoptosis and cytotoxicity, and endocytosis. Chris travels frequently to support collaborative research projects and has given over 300 technical seminars and trainings in over thirty countries as part of a scientific education program.

    Abstract

    Antibody drug conjugates (ADCs) represent a novel method to deliver a drug to diseased cell using the specific antigen-binding capability and internalization process. Antibodies that do not internalize efficiently will have sub-optimal therapeutic results.

    This webinar will introduce reactive chemistries, bright and versatile fluorophores, and powerful detection platforms. You will learn how these novel technologies can advance your ADC discovery and research.

    Learn how to:

    • Use  pH change to detect and measure internalization
    • Perform defined conjugation with the SiteClick™ Antibody Labeling system
    • Quickly and easily screen candidate antibodies for specific internalization

     


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