APR 15, 2020 9:00 AM PDT

Single-cell multi-omics: DNA methylation and 3D genome

Sponsored by: Zymo Research
Speaker
  • Assistant Professor, Cincinnati Children's Hospital Medical Center
    Biography
      Yaping Liu is an Assistant Professor (tenure-track) at Division of Human Genetics in Cincinnati Children's Hospital Medical Center and Department of Pediatrics in University of Cincinnati College of Medicine (2019-). The focus of his lab is on developing and applying machine learning (dry-lab) and high-throughput experimental methods (wet-lab) to understand the gene regulation and non-coding genetic variants. Specifically, we would like to understand the multi-omics heterogeneity in circulating cell-free DNA and its related cell types to explore the role of epigenetics in gene regulation and therefore bridge the gap between genetic and phenotypic variations at different healthy and pathological conditions.

      Prior to joining CCHMC and UC faculty, he was a principal computational biologist at a liquid biopsy company to develop computational methods for cancer early detection in 2018. In 2014-2017, he was a postdoc associate with Dr. Manolis Kellis at the Computer Science and Artificial Intelligence Laboratory (CSAIL) in MIT and Broad institute of MIT and Harvard. In 2014, He received his Ph.D. in Genetics, Molecular and Cellular Biology focused on cancer epigenomics under the supervision of Dr. Benjamin P. Berman at University of Southern California. In 2008, he received his B.S. in Biotechnology from Nanjing University in China.

    Abstract
    DATE:  April 15, 2020
    TIME:  9:00am PT, 12:00pm ET
     
    We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
     
     
     
    Webinars will be available for unlimited on-demand viewing after live event.

    Show Resources
    You May Also Like
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    JUN 09, 2020 3:00 PM CEST
    C.E. CREDITS
    JUN 09, 2020 3:00 PM CEST
    DATE: June 9, 2020 TIME: 6am PT, 9am ET, 3pm CEST The importance of disposable plastic consumables and their overall impact on the experimental workflow of qPCR has been taken into considera...
    JUN 17, 2020 1:30 PM PDT
    C.E. CREDITS
    JUN 17, 2020 1:30 PM PDT
    Understanding the complex interplay between a pathogen and the host response is important to developing effective vaccines and therapeutics. The nCounter® Analysis System and GeoMx®...
    JUN 23, 2020 10:00 AM PDT
    C.E. CREDITS
    JUN 23, 2020 10:00 AM PDT
    DATE: June 23, 2020 TIME: 10:00am PT Human mesenchymal stromal or stem cells (MSCs)-based immunomodulation treatment has been proposed as a suitable therapeutic approach for many diseases, s...
    Loading Comments...
    Show Resources
    Attendees
    • See more