SEP 08, 2020 10:00 AM PDT

Keynote Presentation: Single-cell virus sequencing of influenza infections that trigger innate immunity

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor, Fred Hutch Cancer Research Center, Investigator, Howard Hughes Medical Institute
    Biography

      Jesse Bloom is a professor at the Fred Hutch Cancer Research Center and an Investigator of the Howard Hughes Medical Institute. The Bloom lab uses a mix of experiment and computation to study the evolution of viruses. Jesse received his PhD in Caltech where he worked with Frances Arnold, and then performed postdoctoral work with David Baltimore also at Caltech. Jesse started his own research group at the Fred Hutch in 2011.


    Abstract

    Influenza infections are initiated by just a handful of virions infecting a handful of cells, so it is important to understand what happens in single infected cells. I will describe work that characterizes how the mutations in individual virions affect the outcome of infection in single cells.

    Learning Objectives:

    1. Explain what is measured during single cell transcriptomic experiments

    2. Explain how mutations affect innate immune recognition of influenza infection


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