Science continues to evolve at a rapid pace. Our understanding of laboratory animal behavior and welfare is also growing. The biomedical research community continues to receive criticisms from activists and concerned citizens that our use of the animals is not justified and our care of the animals is inadequate. These concerns are often not based on facts; however, we must continue to seek ways to optimize the conduct of animal studies by adopting the highest ethical standards and practices. Refinements to the way we care for the laboratory animals as well as the way we conduct our studies can lead to large enhancements to both science and animal welfare. Participating in public outreach to explain why we work with animal models and how we provide ethical care for them can help a misinformed public to understand the work we do. Those attending this webinar will learn about how to develop a culture of welfare that is continuously evolving through the implementation of refinements to housing, environment, enrichment, supportive care, humane endpoints, and training and innovative 3Rs initiatives. They will also be encouraged to take a more active role in public outreach to advance public understanding of biomedical research with animal models.