MAY 26, 2020 8:00 AM PDT

Sensitivity, Selectivity, and Speed: Solving Analytical Challenges in Endocrinology using LC-MS/MS for Clinical Research

Sponsored by: Waters Corporation
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Scientist, Waters Corporation
    Biography
      Dominic Foley is a Senior Scientist working at Waters Mass Spectrometry Headquarters in Wilmslow, UK. Having joined the company in September 2013, he has specialized in the development of LC-MS/MS clinical research applications, with a particular focus on steroid hormone analysis. In his role, he also collaborates with clinical customers in the development and implementation of LC-MS/MS methods in their laboratories.
      Dominic has worked in separation sciences for 13 years, following his ambition of improving the quality of healthcare. He started his career with ICON Development Solutions, a CRO in the north of the UK, where he worked as a LC-MS/MS method development and validation scientist supporting DMPK studies in drug discovery. In 2012, he joined Thermo Fisher Scientific to work in their Chromatography R&D team as a Technical Support Specialist, working on the development of new chromatography and sample preparation products.
      Dominic received his BSc (Hons) in Biochemistry from the University of Manchester in 2006. He has presented his work at conferences around the world and has several publications in both the Microchemical Journal and the Journal of Chromatography A.

    Abstract
    DATE:  May 26, 2020
    TIME:  8:00am PDT, 11:00am EDT, 4:00pm BST, 5:00pm CEST
     
    The use of LC-MS/MS technologies in Endocrinology for clinical research is experiencing rapid growth. This is a result of the demonstrated improvements in selectivity, and therefore accuracy, provided by the platform compared to more traditional technologies such as immunoassay. In addition, the ability of LC-MS/MS to monitor large number of analytes in a single method, with improvement in both analytical sensitivity and selectivity, increases the speed at which a sample can be interrogated for biochemical abnormalities. Analytical sensitivity, selectivity and speed are all important aspects of endocrine methodologies which can be augmented by using high sensitivity LC-MS/MS platforms such as the Xevo TQ-S micro and Xevo TQ-XS mass spectrometers. For challenging analyses on these platforms, automation can be employed to simplify the workflow to minimize manual intervention during this process, which helps improve both method robustness and laboratory efficiency.
     
    Learning Objectives:
    • Understand the analytical benefits of using LC-MS/MS for endocrine methods over other platforms
    • Incorporation of selective sample preparation workflows to improve analytical performance
    • Demonstrate how offline automation can be leveraged to improve method performance and optimize efficiency in LC-MS/MS laboratories  
     
     
    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

     


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