MAR 18, 2015 9:00 AM PDT

Special Lecturer - DREADD2.0: an Enhanced Chemogenetic Toolkit

Presented at: Neuroscience
Speaker
  • Director, NIMH Psychoactive Drug Screening Program, Michael Hooker Chair Protein Therapeutics , Professor of Pharmacology, UNC Chapel Hill Medical School Chapel Hill
    Biography
      Bryan L. Roth MD, PhD is the Michael Hooker Distinguished Professor of Protein Therapeutics and Translational Proteomics in the Department of Pharmacology at the University of North Carolina at Chapel Hill Medical School.  Dr. Roth has published more than 300 papers and has given more than 200 invited talks. Dr. Roth has served on the editorial boards of many major scientific journals including the Journal of Biological Chemistry, Molecular Pharmacology, the Journal of Pharmacology and Experimental Therapeutics, ACS Medicinal Chemistry Letters, The Journal of Receptors and Signal Transduction Research, the Journal of Neurochemistry, Pharmacology and Therapeutics, Psychopharmacology and Neuropsychopharmacology.  Dr Roth is currently Associate Editor for the Journal of Clinical Investiagation.   Dr. Roth is also a member of Faculty of 1000.
      <br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
      <br />Dr. Roth has received a number of honors including the PhRMA Foundation Excellence in Pharmacology Award, the Irving Page Lecture, the NARSAD Distinguished Investigator Award, the Heffter Foundation Award for Basic Science Research, the Lowenthal Lecture (Medical College of Virginia), a Prestige Lecture (Universit de Montral), the SG Fergusson Memorial Lecture (Robarts Institute), the Chauncy Leake Memorial Lecture (Univ Texas Medical Branch), the National Institute of Mental Health Career Development Award,&nbsp; a Dana Foundation Fellowship in Neurosciences (Stanford University) and Phi Beta Kappa (St. Louis University).&nbsp; Dr. Roths work has been highlighted and Dr. Roth has been interviewed about his work in the New York Times, the Wall Street Journal, National Public Radios All Things Considered, CBS Early Program, MSNBC, the Los Angeles Times and a large number of other media outlets. Dr. Roth was elected to the Institute of Medicine in 2014.
      <br />

    Abstract

    The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative has the ambitious goal of elucidating how neuronal ensembles interactively encode higher brain processes. To accomplish this goal, new and improved methods for both recording and manipulating neuronal activity will be needed. In this thal, I will focus on technologies for manipulating neuronal activity. In particular I will present an enhanced chemogenetic toolbox that allows non-invasive, multiplexed spatiotemporal control of neuronal activity in domains ranging from single synapses to ensembles of neurons.


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