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APR 23, 2020 9:00 AM PDT

Keynote Presentation: Individualized Health

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Stanford Ascherman Professor, Chair of Genetics Director of the Center of Genomics and Personalized Medicine
    Biography
      Michael Snyder is the Stanford Ascherman Professor and Chair of Genetics and the Director of the Center of Genomics and Personalized Medicine. Dr. Snyder received his Ph.D. training at the California Institute of Technology and carried out postdoctoral training at Stanford University. He is a leader in the field of functional genomics and multiomics, and one of the major participants of the ENCODE project. His laboratory study was the first to perform a large-scale functional genomics project in any organism, and has developed many technologies in genomics and proteomics. These including the development of proteome chips, high resolution tiling arrays for the entire human genome, methods for global mapping of transcription factor (TF) binding sites (ChIP-chip now replaced by ChIP-seq), paired end sequencing for mapping of structural variation in eukaryotes, de novo genome sequencing of genomes using high throughput technologies and RNA-Seq. These technologies have been used for characterizing genomes, proteomes and regulatory networks. Seminal findings from the Snyder laboratory include the discovery that much more of the human genome is transcribed and contains regulatory information than was previously appreciated (e.g. lncRNAs and TF binding sites), and a high diversity of transcription factor binding occurs both between and within species. He has also combined different state-of-the-art "omics" technologies to perform the first longitudinal detailed integrative personal omics profile (iPOP) of person and used this to assess disease risk and monitor disease states for personalized medicine. He is a cofounder of many biotechnology companies, including Excelix, Personalis, SensOmics, Qbio, January, Protos, Oralome, Mirvie and Filtricine.

    Abstract

    Recent technological advances as well as longitudinal monitoring not only have the potential to improve the treatment of disease (Precision Medicine) but also empower people to stay healthy (Precision Health). We have profiled 109 participants using multiomics technologies (genomics, immunomics, transcriptomics, proteomics, metabolomics, microbiomics and wearables etc) for up to 9.5 years and made 49 major health discoveries. We have also profiled people after an acute bout of exercise and found that thousands of blood molecules change after a short bout of exercise. Lastly, we demonstrate that individuals have distinct aging patterns that can be measured in a period of time that is actionable. We conclude that deep longitudinal profiling can lead to actionable health discoveries and provide relevant information for precision health.

    Learning Objectives:

    1. What is wrong with healthcare today

    2. What kinds of omics and wearables data can be used to best predict disease risk and manage health


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