SEP 10, 2020 6:00 AM PDT

Structure-guided design of SARS-CoV-2 antivirals

Speakers
  • Assistant Professor Principal Investigator ShanghaiTech University
    Biography

      Professor Quan Wang is committed to using cryo-electron microscopy to study the composition and structure of important biomolecules and complexes of pathogenic microorganisms and the molecular mechanisms of host immune systems in response to pathogen infection. At the same time, he also works on the relevant anti-infective drugs screening and development.

    • Postdoctoral Researcher Westlake University
      Biography

        Dr. Renhong Yan received his Ph.D. degree in biochemical & structural biology from Tsinghua University mentored by Prof. Nieng Yan in 2019. He is a Postdoctoral Researcher at Westlake University focusing on the structure and function of membrane proteins. His major research interests are the human amino acid transporter complex and phospholipid metabolism regulators.


      Abstract

      Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is spreading rapidly across the world and was announced as a “global pandemic” by the World Health Organization (WHO) on 11 March 2020. SARS-CoV-2 is a new member of the betacoronavirus genus and closely related to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Insights to the molecular basis for coronavirus recognition and infection holds promise for therapy.Cryo-EM studies are now shedding light on key molecular processes including RNA replication/transcription and receptor recognition. These findings provide important insights to the molecular basis for coronavirus recognition, infection and ultimately, the design of new antiviral therapeutics.

      Learning Objectives:

      1. Full-length ACE2 recognition by SARS-CoV-2

      2. RNA-dependent RNA polymerase nsp12 in complex with cofactors nsp7 andnsp8

      3. Design of Corona-targeting antiviral medicines


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