MAY 24, 2017 07:30 AM PDT
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Case Studies: Scaling Cell Therapy Manufacturing
Presented at the Lab Automation 2017 Virtual Event
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  • Senior Cell Processing Specialist, Terumo BCT
      Prior to joining the Cell Processing team at Terumo BCT, Dr. Beltzer was the lead scientist for the research and development of Corning® Synthemax®, a synthetic growth surface for the culture of human embryonic stem cells at Corning Life Sciences. He was a co-founder of RETT Corporation and was a key player in the industrialization of several technology platforms, including phage display and yeast two-hybrid. He has more than 20 years of industrial research and development experience in a broad range of disciplines.


    Gain insights into T-cell expansion, viral vector production and scaling production of mesenchymal stem cells (MSCs) through the use of a functionally closed, automated, cell culture process.

    Dr. Beltzer (Terumo BCT, CO, U.S.) will present a number of case studies to describe how process development and economic goals were achieved in both industry and academic settings. Results include up to a 500-fold expansion of T-cells in 12 days, 40 percent reduction in cost of goods (COGs) of growing cells for an allogeneic therapy, and automated viral vector production with titers similar to flask-based processes. Particular attention will be directed toward the process changes often needed to meet these goals.

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