JUN 30, 2016 8:00 AM PDT

Surveying expression of immune checkpoint markers in the tissue microenvironment

Speaker
  • Research Scientist, R&D, Advanced Cell Diagnostics (ACD)
    Biography
      Dr. Jeffrey Kim is an research scientist at Advanced Cell Diagnostics (ACD) in Newark, California. Dr. Kim obtained his Ph.D. in molecular biology investigating how nutrient metabolism impacts gene expression to alter chronic disease states at the University of Connecticut. Afterwards, he completed a postdoctoral fellowship at the University of California-Davis looking at oncometabolite metabolism in renal cell carcinoma as well as the role of docosahexaenoic acid-derived metabolites on tumor angiogenesis. In addition, he previously completed a fellowship at the National Institutes of Health examining the influence of various fatty acids on brain development by combining the powerful tools of mass spectrometry and imaging.

    Abstract

    DATE:  June 30, 2016
    TIME:  8:00am Pacific time, 11:00am Eastern time

    Focusing solely on malignant cancer cells and the genes that they express is modestly just a glimpse of the larger picture. The tumor microenvironment (TME) plays an important role in both tumor progression and the potential treatment response; identifying the key players involved in this environment could further reveal the immune system’s potential to regulate cancer. To achieve this, we used RNAscope® Assay to visualize immune checkpoint markers in the TME of non-small cell lung carcinoma biopsies from patients. Detection of co-expressed markers revealed a diverse pattern, highlighting intratumor heterogeneity within each tumor. Information derived from this study may reveal potential insight into combination therapies targeted against different checkpoint pathways.
     
    Learning objectives:

    • Understand how gene expression can be distinctly revealed with RNAscope in formalin-fixed, paraffin-embedded tissues with reliable consistency.
    • Learn how screening for checkpoint markers in the TME can help assess potential effective therapies.

    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    MAR 31, 2020 9:00 AM PDT
    C.E. CREDITS
    MAR 31, 2020 9:00 AM PDT
    DATE: March 31, 2020 TIME: 9:00am PT, 12:00pm ET HER2-positive breast cancer is a type of breast cancer caused by over-expression of a protein called human epidermal growth factor receptor 2...
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
    Loading Comments...
    Show Resources
    Attendees
    • See more