MAY 28, 2014 07:30 AM PDT

Technical Challenges and Standardization of Vitamin D

Speakers
  • Director, Assay Development, Siemens Healthcare Diagnostics
    Biography
      Jim Freeman, Director of Assay Development for Siemens Healthcare Diagnostics in Tarrytown, NY,  is responsible for the development of infectious  disease, endocrinology, and bone metabolism assays on the ADVIA Centaur Systems. Jim graduated from San Jose State University with a B.S. in biochemistry and began his career in diagnostics in 1984 at Syntex Medical Diagnostics Division (SMDD), a subsidiary of Syva Co. At SMDD, he helped develop dipstick immunoassays for therapeutic drugs. During his tenure at Siemens, Jim created a finger-stick assay for cholesterol and HDL cholesterol as well as several immunoassays for the Technicon Immuno 1 Immunoassay analyzer, including carbamazepine, valproic acid, toxoplasma IgG, toxoplasma IgM, and H. pylori. As manager of the Monoclonal and Polyclonal Antibody Development Group, he developed several monoclonal and polyclonal antibodies used in several commercialized products. In January 2000, Jim joined the Assay Development Group to work on infectious-disease immunoassays for the ADVIA Centaur systems. He developed both the ADVIA Centaur EHIV and CHIV assays. Jim is also responsible for the development of the ADVIA Centaur procalcitonin, estradiol, and Toxo IgM II assays, as well as of several assays currently in development. The ADVIA Centaur Vitamin D Total Assay is the latest addition to his 25-year career in immunoassay development. Jim has authored several published articles and holds four patents, with four more pending approval.

    Abstract:


    Variability of vitamin D results remains a hot topic today as more options are available to laboratories. This webinar examines how clinical and analytical factors such as vitamin D binding protein (DBP), 3-epi-25(OH)vitamin D3, and vitamin D2 supplementation may impact vitamin D values, and how these in turn may impact clinical decisions. It also discusses how initiatives such as the NIH Office of Dietary Supplements Vitamin D Standardization Program (VDSP) will improve standardization of results.

    Learning objectives:
    Understand the clinical and analytical factors that influence the measurement of vitamin D by immunoassay and how they impact patient results.
    Learn about the implementation of the Vitamin D Standardization Program and the next steps in vitamin D harmonization.


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