SEP 16, 2014 8:30 AM PDT

The use of transcriptional signatures for clinical population selection

Speaker

Abstract
The use of biomarkers for the stratification of populations for therapy is a concept that holds the potential to revolutionize clinical trial design, the economics of healthcare, and most importantly, the future treatment of cancer patients. While single-gene aberrations are currently being used as predictive biomarkers in oncology clinical trial design, the use of multi-gene biomarkers such as transcriptional signatures is not common, despite the fact that multi-gene signatures may be more likely to provide the high sensitivity and specificity required for biomarkers to be validated for clinical practice. The Compendia Bioscience Translational Bioinformatics Services team has expertise in generation and refinement of transcriptional biomarkers of response. These signatures of response and resistance can be utilized to support many aspects of drug development, including understanding mechanism of action, building a competitive differentiation plan, and identification of drug combination opportunities. In this session, Dr. Urick will discuss the potential utility of transcriptional signatures as predictive biomarkers as well as highlight the current techniques used by the Compendia Bioscience Translational Bioinformatics Services team to utilize transcriptional signatures for potential clinical trial population selection.

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
JUN 09, 2021 7:00 AM PDT
C.E. CREDITS
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
JUL 15, 2021 9:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
JUL 15, 2021 9:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: July 15, 2021 Time: 9:00am (PDT), 12:00pm (EDT) The Pisces workflow robust, easy-to-use, end-to-end multi-omics solution for highly multiplexed targeted Spatial RNA analysis. VeranomeB...
JUN 24, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
JUN 24, 2021 7:00 AM PDT
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: June 24, 2021 Time: 7:00am (PDT), 10:00am (EDT), 4:00pm (CEST) Problem: A comprehensive mechanistic understanding of how genetic alterations impact cancer development and therapeutic i...
JUN 03, 2021 8:00 AM PDT
JUN 03, 2021 8:00 AM PDT
Date: June 3, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Molecular combing provides unbiased quantification and characterization of DNA structure and dynamics by imaging single DN...
Loading Comments...
Show Resources