SEP 16, 2014 08:30 AM PDT

The use of transcriptional signatures for clinical population selection

Speakers

Abstract:
The use of biomarkers for the stratification of populations for therapy is a concept that holds the potential to revolutionize clinical trial design, the economics of healthcare, and most importantly, the future treatment of cancer patients. While single-gene aberrations are currently being used as predictive biomarkers in oncology clinical trial design, the use of multi-gene biomarkers such as transcriptional signatures is not common, despite the fact that multi-gene signatures may be more likely to provide the high sensitivity and specificity required for biomarkers to be validated for clinical practice. The Compendia Bioscience Translational Bioinformatics Services team has expertise in generation and refinement of transcriptional biomarkers of response. These signatures of response and resistance can be utilized to support many aspects of drug development, including understanding mechanism of action, building a competitive differentiation plan, and identification of drug combination opportunities. In this session, Dr. Urick will discuss the potential utility of transcriptional signatures as predictive biomarkers as well as highlight the current techniques used by the Compendia Bioscience Translational Bioinformatics Services team to utilize transcriptional signatures for potential clinical trial population selection.

Show Resources
You May Also Like
MAY 24, 2018 09:30 AM PDT
C.E. CREDITS
MAY 24, 2018 09:30 AM PDT
DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
AUG 15, 2018 08:00 AM PDT
C.E. CREDITS
AUG 15, 2018 08:00 AM PDT
DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
APR 27, 2018 10:00 AM PDT
C.E. CREDITS
APR 27, 2018 10:00 AM PDT
DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
MAY 24, 2018 09:00 AM PDT
C.E. CREDITS
MAY 24, 2018 09:00 AM PDT
Recent advances in immuno-oncology research has proven the critical role of immune cells in cancer therapy. Deep understanding of the interaction and phenotype of immune and tumor cells withi...
MAY 03, 2018 08:00 AM PDT
C.E. CREDITS
MAY 03, 2018 08:00 AM PDT
DATE:  May 3rd, 2018TIME:   8:00 AM PDT, 11:00 AM EDTIntestinal inflammation is a hallmark of the inflammatory bowel diseases (IBD), including ulcerative colitis and Cr...
JUN 26, 2018 06:00 AM PDT
C.E. CREDITS
JUN 26, 2018 06:00 AM PDT
Date: June 26, 2018Time: 6:00 a.m. PDT, 9:00 a.m. EDT, 1500 CEST Today’s hematology analyzers employ various methods for enumerating platelets. These methods include: e...
Loading Comments...