SEP 16, 2014 8:30 AM PDT

The use of transcriptional signatures for clinical population selection

Speaker

Abstract
The use of biomarkers for the stratification of populations for therapy is a concept that holds the potential to revolutionize clinical trial design, the economics of healthcare, and most importantly, the future treatment of cancer patients. While single-gene aberrations are currently being used as predictive biomarkers in oncology clinical trial design, the use of multi-gene biomarkers such as transcriptional signatures is not common, despite the fact that multi-gene signatures may be more likely to provide the high sensitivity and specificity required for biomarkers to be validated for clinical practice. The Compendia Bioscience Translational Bioinformatics Services team has expertise in generation and refinement of transcriptional biomarkers of response. These signatures of response and resistance can be utilized to support many aspects of drug development, including understanding mechanism of action, building a competitive differentiation plan, and identification of drug combination opportunities. In this session, Dr. Urick will discuss the potential utility of transcriptional signatures as predictive biomarkers as well as highlight the current techniques used by the Compendia Bioscience Translational Bioinformatics Services team to utilize transcriptional signatures for potential clinical trial population selection.

Show Resources
You May Also Like
DEC 02, 2020 8:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
C.E. CREDITS
DEC 02, 2020 8:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
DEC 07, 2020 9:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
DEC 07, 2020 9:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
Date: December 7, 2020 Time: 9:00am (PST), 12:00pm (EST) The simultaneous detection of biomarkers on tissue samples plays a fundamental role in the study of the tumor microenvironment. Multi...
AUG 25, 2020 8:00 AM PDT
C.E. CREDITS
AUG 25, 2020 8:00 AM PDT
DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
OCT 29, 2020 6:00 AM PDT
C.E. CREDITS
OCT 29, 2020 6:00 AM PDT
Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
NOV 18, 2020 8:00 AM PST
C.E. CREDITS
NOV 18, 2020 8:00 AM PST
DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
SEP 10, 2020 9:00 AM PDT
C.E. CREDITS
SEP 10, 2020 9:00 AM PDT
Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
Loading Comments...
Show Resources