MAY 25, 2017 06:00 AM PDT

In-House Technology Development for Next Gen Sequencing, Tissue Handling and beyond, at the BC Cancer Agency

C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Instrumentation Group Leader, BC Cancer Agency Genome Sciences Centre
    Biography
      Robin Coope is the Instrumentation Group Leader at the BC Cancer Agency's Genome Sciences Centre and has been in the genomics field since 2000. In this position Dr. Coope is responsible for evaluating new instrumentation as well as designing de-novo solutions. He holds a BASc and MASc in Engineering Physics and a PhD in Physics from the University of British Columbia. At the GSC, Dr. Coope led several large scale automation efforts including mechanizing a large scale genomic mapping pipeline to characterize large scale rearrangements in follicular lymphoma genomes and more recently, leading the development of the first 96 channel size selection robot for NGS sample preparation. The latter has recently been licensed to a spinoff company, Coastal Genomics, who are commercializing it. As co-director of the Genome British Columbia Technology Development Platform, Dr. Coope has also been involved in several biomedical device development projects, including a novel implant for minimally invasive fixation of pelvic fractures, which has also been recently been licensed. He has published on solid state physics, display research and genome and biology and technology.

    Abstract:

    The Instrumentation Group at the BC Cancer Agency’s Genome Sciences Centre (GSC) is unusual in having an engineering group and extensive prototyping facilities embedded in a biomedical research and clinical cancer treatment facility. The group has completed numerous pipeline-specific automation projects, and in one case, enabled the GSC to participate in a major international consortium based on our in-house technology. In-house solutions range from simple manual devices to components integrated with liquid handlers, to full robots as well as ongoing programming of the GSC’s liquid handlers. This presentation will highlight significant projects and some lessons in efficient prototyping and good software practices that have been learned.

    The group’s primary role is programming the GSC’s commercial liquid handling robots, working closely with our methods development, quality assurance and production teams. This joint approach, with expert molecular biologists working in tandem with expert programmers and independent QA, has produced robust methods for a variety of sample types. In fact, we have harmonized chemistry and liquid handling protocols to the extent that nine different NGS library types (PCR-free gDNA, FFPE DNA, RNAseq, CHiP, Bisulfite Seq, (exome or other) capture samples and circulating cell free gDNA) run under one main program. This has substantial advantages but also potential pitfalls, which will be described.


    Show Resources
    You May Also Like
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    JUN 26, 2019 09:00 AM PDT
    C.E. CREDITS
    JUN 26, 2019 09:00 AM PDT
    DATE: June 26, 2019TIME: 9:00am PDT, 12:00pm EDT An excessive number of software solutions are available to help manage your clinical, biobank, or biorepository sample inform...
    NOV 18, 2019 08:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    NOV 18, 2019 08:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: November 18, 2019TIME: 8:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    Loading Comments...
    Show Resources