MAR 13, 2019 1:40 PM PDT

Clinical Updates: Towards Artificial Intelligence Based Adaptive Deep Brain Stimulation in Movement Disorders

Presented at: Neuroscience 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Clinician Scientist, Movement Disorders and Neuromodulation Unit at the Department of Neurology, Charité - Universitätsmedizin Berlin, Germany
    Biography
      Wolf-Julian Neumann, MD, is a clinician scientist in the Movement Disorders and Neuromodulation Unit at the Department of Neurology at the largest European University Hospital, Charité - Universitätsmedizin Berlin, Germany. His doctoral thesis describes invasive oscillatory biomarkers for major depressive disorder from the human limbic system. He has built his expertise in Movement Disorders and Neurophysiology during his postdoctoral research in Berlin under supervision from Andrea A. Kühn. Research visits to the Wellcome Centre for Integrative Neuroimaging in Queen Square, London (Prof. Dr. Vladimir Litvak) and the Department of Functional Neurosurgery at University of Pittsburgh (Prof. Dr. R. Mark Richardson) have complemented his methodological expertise.

      He since develops methods for multimodal and multidimensional data analysis for clinical neuroscience applications. His current work combines computational modelling, deep learning, structural and functional connectivity mapping (fMRI), invasive (LFP/ECoG) and non-invasive (EEG/MEG) recordings, to elucidate the role of the basal ganglia in health and disease.

    Abstract

    Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high-frequency stimulation can mimic the effects of ablative neurosurgery in Parkinson's disease (PD), while offering two key advantages to previous procedures: adjustability and reversibility. Deep brain stimulation is now an established therapeutic approach that robustly alleviates symptoms in patients with movement disorders, such as Parkinson's disease, essential tremor, and dystonia, who present with inadequate or adverse responses to medication. Currently, stimulation electrodes are implanted in specific target regions of the basal ganglia-thalamic circuit and stimulation pulses are delivered chronically. Next-generation stimulation strategies will capitalize on recent advances in recurrent artificial neural networks to inspire intelligent neural prosthetics that learn when patients sleep, walk, speak or exhibit symptoms such as tremor or bradykinesia. This talk will give detailed insight into potential biomarkers and discuss neurosurgical and computational strategies, implementing advances in artificial intelligence, to further elevate the therapeutic potential of DBS by capitalizing on its modifiable nature. Development of intelligent aDBS, with an ability to deliver highly personalized treatment regimens and to create symptom-specific therapeutic strategies in real-time, could allow for significant further improvements in the quality of life for movement disorders patients with DBS that ultimately could outperform traditional drug treatment.


    Show Resources
    You May Also Like
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    SEP 10, 2020 9:00 AM PDT
    C.E. CREDITS
    SEP 10, 2020 9:00 AM PDT
    Date: September 10, 2020 Time: 9:00am (PDT), 12:00pm (EDT) Osmolality testing is relevant throughout the entire bioprocessing workflow. As customers look to refine mAb and gene therapy workf...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    OCT 08, 2020 7:00 AM PDT
    C.E. CREDITS
    OCT 08, 2020 7:00 AM PDT
    DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
    MAR 13, 2019 1:40 PM PDT

    Clinical Updates: Towards Artificial Intelligence Based Adaptive Deep Brain Stimulation in Movement Disorders

    Presented at: Neuroscience 2019
    C.E. Credits: P.A.C.E. CE Florida CE

    Specialty

    Assay Development

    Molecular Biology

    Lims

    Lab Automation

    Brain

    Genomics

    Spectroscopy

    Gene Expression

    Precision Medicine

    Bioinformatics

    Molecular Diagnostics

    Mass Spectrometry

    Laboratory Testing

    Genotyping

    Toxicology

    Geography

    North America50%

    Registration Source

    Website Visitors100%

    Job Title

    Medical Laboratory Technician50%

    Post Doc50%

    Organization

    Clinical Laboratory50%

    Other50%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more