MENU
NOV 15, 2018 2:00 AM PST

Towards commercial manufacture of pluripotent stem cell derived therapies

Speaker
  • Senior Scientist, Cell and Gene Therapy Catapult
    Biography
      Rhys Macown, Ph.D, is a senior scientist in the process industrialisation team at Cell and Gene Therapy Catapult UK. Rhys earnt a BE(Hons) in chemical and process engineering at University of Canterbury (NZ) before starting his career with a PhD in biochemical engineering in Prof. Nicolas Szita's group at University College London. There he designed and tested a microfluidic system for the 2D adherent culture of pluripotent stem cells with fine control over the micro-environment. Since joining the Cell and Gene Therapy Catapult in 2014, Rhys has been continually active on fee-for-service, collaborative, and core-funded projects developing pluripotent stem cell based processes and has played a leading role exploring the 3D expansion of pluripotent stem cells as aggregates.

    Abstract

    In contrast to autologous cell therapies, allogeneic therapies do not require collection of starting material from patients and could: be manufactured in larger batches, be made available “off-the-shelf”, and potentially utilise established biopharma manufacturing technologies. Despite this, allogeneic therapies constitute half of pre-clinical trials and a third of clinical trials in the UK. In an addition to the potential for an immune response, another major barrier to the adoption of allogeneic therapies is current manufacturing cost which increases when using pluripotent stem cells (PSC) as starting material. The manufacturing process is often open and manual, utilising 2D, adherent culture systems and xeno or serum containing materials. As such, these processes are regulatorily challenging and impractical to scale-up to meet market demands. This talk will cover our work to date and future plans in addressing these barriers and realising the potential of PSC-derived allogeneic therapies.

    The Cell and Gene Therapy (CGT) Catapult have been working to address some of the challenges of manufacturing processes for PSC derived therapies, towards improving commercial viability. We used regulatorily amenable starting materials, developed invasive and non-invasive methods for process characterisation, developed exemplar processes for the expansion of pluripotent aggregates in stirred tank reactors, and developed concentration and wash processes for large-scale PSC processing. CGT Catapult’s next development focuses are the scale-up and intensification of PSC expansion in stirred tank reactors, translation of differentiation processes to automated and scalable culture systems, and cost of goods reduction.


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    JUN 03, 2021 12:00 PM CST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    JUN 03, 2021 12:00 PM CST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: June 3, 2021 TIME: 12:00pm SGT This webinar is a virtual event that focuses on utilizing the Gibco CTS Rotea System for Cell and Gene Therapy...
    APR 21, 2021 5:00 PM CEST
    APR 21, 2021 5:00 PM CEST
    Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
    DEC 09, 2020 9:00 AM PST
    C.E. CREDITS
    DEC 09, 2020 9:00 AM PST
    DATE: December 09, 2020 TIME: 09:00am PST Hematopoietic stem cells (HSCs) ensure homeostasis of blood throughout life. In this webinar, we share insights into the smart and easy isolation, c...
    NOV 15, 2018 2:00 AM PST

    Towards commercial manufacture of pluripotent stem cell derived therapies


    Specialty

    Molecular Biology

    Cell Biology

    Genetics

    Cell Line Development

    Cancer Research

    Clinical Research

    Medicine

    Biotechnology

    Assay Development

    Diagnostics

    Human Biology

    Clinical Diagnostics

    Drug Discovery

    Systems Biology

    Biology

    Geography

    North America30%

    Asia28%

    Europe26%

    Africa12%

    Oceania3%

    Registration Source

    Website Visitors88%

    WAVE Newsletter Promotion3%

    Client/Sponsor Promotions3%

    Social Media Promotions1%

    Other4%

    Job Title

    Student36%

    Research Scientist21%

    Post Doc9%

    Executive8%

    Medical Doctor/Specialist8%

    Scientist6%

    Pathologist2%

    Facility/Department Manager2%

    Biologist2%

    Engineer2%

    Clinical Laboratory Scientist2%

    Marketing/Sales2%

    Educator/Faculty2%

    Organization

    Academic Institution22%

    Research Institute14%

    Biotech Company14%

    Medical School9%

    Hospital7%

    Clinical Laboratory6%

    Government6%

    Pharmaceutical Company3%

    Contract Research Organization (Cro)3%

    Medical Center3%

    Life Science Company1%

    Medical Device Company1%

    Industrial Company1%

    Other7%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more