OCT 17, 2017 08:00 AM PDT

WEBINAR: Transcriptomics to decipher the pathobiology of drug resistance and enable targeted therapeutics

Speakers
  • Assistant Research Professor, Department of Pathology and Laboratory Medicine, Indiana University School of Medicine
    Biography
      Dr. Yesim Gökmen-Polar is an Assistant Research Professor in the Department of Pathology and Laboratory Medicine at Indiana University School of Medicine. Her research interests are centered on the identification of novel therapeutic targets in breast and thymic cancers resistant to standard of care therapy. She has approximately 50 publications mainly in the field of cancer biology. Her specific expertise is in development of novel therapeutic targets (i.e. targeting EphA2 receptor tyrosine kinase, protein kinase C beta, anti-tubulins and TORC1/2) in colon, breast cancer and thymic malignancies. Her lab developed and characterized a novel human thymoma model, designated as IU-TAB-1, which was derived from a patient with the stage II thymoma (WHO type A/B). Dr. Gökmen-Polar's current research uses next generation sequencing (NGS), next generation microarrays such as Clariom D Human Transcriptome Analysis, and preclinical models to understand the transcriptional regulation/mechanisms of resistance and develop novel targeted therapies. The ultimate goal of her research is to prevent development of recurrences and improve the quality of life for patients.

    Abstract:

    DATE: October 17, 2017
    TIME: 08:00am PDT, 11:00am EDT

    Researching and understanding the mechanisms of drug resistance are essential to determine therapies that are more effective on an individual basis. Computational biology tools combined with transcriptome analysis allow the characterization of differential gene expression signatures in response to treatment in resistant vs non-resistant human-derived cancer cells. Many biomarkers including non-coding RNAs and alternatively spliced variants have been associated with tumor pathogenesis or drug resistance. These biomarkers represent candidates to help elucidate the biology of diseases, to identify the mechanisms for drug resistance, and to design better targeted therapies for precision medicine.

     

    In this webinar, the speaker will:

    • Explain the importance of non-coding RNAs and alternative splicing in cancer biology
    • Describe transcriptomics workflows to identify biomarkers and drug resistance mechanisms
    • Share applications in breast and thymic cancer research

     

    For Research Use Only. Not for use in diagnostic procedures.


    Show Resources
    You May Also Like
    NOV 18, 2019 07:00 AM PST
    C.E. CREDITS
    NOV 18, 2019 07:00 AM PST
    DATE: November 18, 2019TIME: 7:00am PST, 11:00am EST, 4:00pm CEWT How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop th...
    JAN 23, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JAN 23, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: TIME: adadf adfadf...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    OCT 02, 2019 11:00 AM PDT
    OCT 02, 2019 11:00 AM PDT
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    FEB 26, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    FEB 26, 2020 09:00 AM PST
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    Loading Comments...
    Show Resources