SEP 26, 2019 12:00 PM PDT

Understanding the Regulation of Membrane Curvature During Mating in Tetrahymena Thermophila

Presented at: Cell Biology 2019
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor of Biology, Millsaps College
    Biography
      Sabrice Guerrier is an Associate Professor of Biology at Millsaps College. He earned a Ph.D. in Pharmacology at The University of North Carolina at Chapel Hill and was a postdoctoral fellow at the Mayo Clinic-Rochester. Following a Howard Hughes Medical Institute (HHMI) funded visiting professorship at Carleton College, Sabrice joined the faculty at Millsaps College. At Millsaps, Sabrice teaches a variety of cell biology course and his research lab uses the ciliate, Tetrahymena thermophila to identify and characterize molecules that regulate membrane curvature.

    Abstract

    The active shaping of biological membranes is essential for a variety of cellular functions including but not limited to cell migration, cell division, organelle morphology, and cell and membrane fusion. To this end, cells have evolved the ability to shape membranes through interactions between lipids and membrane shaping proteins or through direct modification of membrane lipids. Exactly how and when cells choose to employ these distinct membrane shaping tools remains a topic of intense study. Using the ciliate, Tetrahymena thermophila, our lab is trying to identify novel membrane shaping mechanisms and the signaling pathways by which they are regulated. 

    Learning Objectives: 

    1. Tetrahymena mating requires cell-cell fusion and selective autophagy 
    2. Membrane shaping proteins, Reticulon and SNX4, may play a role in cell-cell fusion and selective autophagy respectively


     


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