OCT 20, 2020 9:00 AM PDT

Understanding how in vitro macrophage assays drive IO drug development forward

Sponsored by: Miltenyi Biotec
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Scientist at ImmunXperts, a Nexelis Group Company
    Biography

      Thibaut holds a Master's degree in Biochemistry, Molecular and Cellular biology from the University of Liège. He received his PhD (2012-2016) at the GIGA research center in Liège, where he acquired strong experience in the immunology field, working on dendritic cells and T cell interactions. During this period, he also developed an in-depth knowledge of flow cytometry. He joined ImmunXperts as a Senior Scientist at the beginning of 2017.


    Abstract

    DATE:  October 20th, 2020

    TIME:   09:00am PDT, 12:00pm EDT

     

    Tumor-associated macrophages (TAMs) are key cells in the tumor microenvironment (TME) with diverse immune functions that have a major influence on tumorigenesis. Thus, TAMs have gained increasing attention as promising targets for the development of effective anti-cancer immunotherapy. In pre-clinical drug discovery research, in vitro macrophage assays are commonly performed to monitor the effect of immunotherapeutic candidates. These assays represent a helpful tool in predicting the effect of immunotherapeutics on TAMs in vivo.
     
    Learning Objectives:

    • Understand the benefits of using human-derived myeloid cells for in vitro assays in pre-clinical drug discovery research
    • Learn about the importance of in vitro macrophage polarization assays to help evaluate pro- and anti-inflammatory phenotypes
    • Get insights on the use of in vitro myeloid suppressive assays for the functional evaluation of candidates
    • Understand the role of phagocytosis and ADCP assays for candidate monitoring

     

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    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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