Name: Anti-PROM1 (XP5-952) h(4-1BB-CD3_) CAR-iT Cells
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Anti-PROM1 (XP5-952) h(4-1BB-CD3_) CAR-iT Cells | Creative Biolabs

Many different strategies are being investigated to develop ""off-the-shelf"" CAR T-cell therapies. The cumbersome manufacturing process and high cost of autologous CAR T cells may prevent some patients from receiving the treatment. Using induced pluripotent stem cells (iPSCs) as a starting source for CAR T cells is an attractive approach.

Our CAR-iT cells are engineered by incorporating a second-generation CAR into iPSCs-derived T cells using lentiviral transduction technology. These CAR-iT cells are expected to lysis tumor cells in vitro and demonstrated anti-tumor function in vivo.