DEIASL036 detects complement factor B activation fragment.
The ELISA kit measures the amount of the complement fragment Bb, an activation fragment of Factor B of the alternative pathway of complement, in human plasma or serum. Measurement of Bb in human plasma or serum provides evidence of the involvement of the alternative pathway of complement. Measurement of alternative pathway activation aids in the diagnosis of several kidney diseases, e.g., chronic glomerulonephritis, lupus nephritis, as well as several skin diseases, e.g., dermatitis herpetiformis and pemphigus vulgaris. Other diseases in which activation of the alternative pathway of complement has been observed include rheumatoid arthritis, sickle cell anemia, and gram-negative bacterial infections.