From pixels to proteomes: Advanced spatial proteomics workflows for transformative biological insights

Spatial proteomics represents a revolutionary frontier in molecular biology, enabling researchers to explore protein expression while preserving the critical spatial context of tissue architecture. Antibody-based spatial methods have provided valuable insights into tissue organization and cellular interactions, and now mass spectrometry-based approaches offer complementary capabilities to extend these discoveries. By combining the specificity of imaging with the comprehensive profiling power of mass spectrometry, researchers can now achieve unprecedented proteome depth—capturing thousands of proteins from minimal sample inputs while maintaining spatial information.

Join our webinar to discover two cutting-edge mass spectrometry-powered spatial proteomics approaches. Dr. Lisa Schweizer will present on Deep Visual Proteomics (DVP), an innovative workflow that combines high-plex imaging with laser microdissection and Thermo Scientific Orbitrap mass spectrometers to achieve deep proteomic profiling of specific cell populations. Dr. Max Ruwolt will demonstrate the Syncell targeted extraction workflow, which enables precise isolation and molecular characterization of selected populations from complex tissue environments.

This webinar will demonstrate how Orbitrap-powered spatial proteomics enables unbiased discovery of novel proteins and pathways, revealing hidden biological insights beyond conventional methods

Learning Objectives:

• Learn how mass spectrometry can benefit spatial proteomics research
• Learn about Deep Visual Proteomics and targeted extraction workflows for spatial analysis
• Discover practical applications that demonstrate how spatial proteomics reveals new biological insights