mouse monoclonal IgG1; Dynamin I Antibody (D5) is an IgG1 κ mouse monoclonal Dynamin I antibody (also designated Dynamin I antibody) that detects the Dynamin I protein of mouse, rat, human, canine and avian origin by WB, IP and IF. Dynamin I Antibody (D5) is available as both the non-conjugated anti-Dynamin I antibody form, as well as multiple conjugated forms of anti-Dynamin I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the Dynamin family, including Dynamin I and Dynamin II, are GTPase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity). The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.