Companies / Santa Cruz Biotechnology / IFN-γRβ (MOB-47) PE
Santa Cruz Biotechnology

IFN-γRβ (MOB-47) PE | Santa Cruz Biotechnology

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hamster monoclonal IgG; IFN-γ induces a variety of biological responses, such as antiviral, antiproliferative and immunomodulatory activity in sensitive cells. Activation of the IFN-γ receptor (IFN-γR) leads to autophosphorylation of the Janus kinases JAK1 and JAK2, and the nuclear translocation of the transcription factors Stat1α p91 and Stat1β p84. The IFN-γR is composed of at least two chains, designated IFN-γRα and IFN-γRβ, respectively (7–9). Although expression of IFN-γRα is sufficient for ligand binding, it alone does not confer responsiveness to IFN-γ. Concomitant expression of IFN-γRα and IFN-γRβ is required for transcriptional activation of IFN-γ-inducible genes. The IFN-γRβ chain, also called AF-1, is 332 and 337 amino acids in length in mouse and human, respectively, and may represent the signal transducing component of the IFN-γR.

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ABOUT THE COMPANY

Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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