mouse monoclonal IgG2b; IFN-γRα Antibody (GIR-94) is an IgG2b κ mouse monoclonal IFN- gamma R alpha antibody (also designated IFNGR1 antibody, Interferon Gamma Receptor 1 antibody, IFN-Gamma Receptor 1 antibody, IFN-Gamma-R-Alpha antibody, CD119 Antigen antibody, IFN-Gamma-R1 antibody, CDw119 antibody, Interferon-Gamma Receptor Alpha Chain antibody, Interferon Gamma Receptor Alpha-Chain antibody, or Immune Interferon Receptor 1 antibody) that detects the IFN- gamma R alpha protein of mouse, rat and human origin by WB, IP, IF and FCM. IFN-γRα Antibody (GIR-94) is available as both the non-conjugated anti-IFN- gamma R alpha antibody form, as well as multiple conjugated forms of anti-IFN- gamma R alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. IFN-γ induces a variety of biological responses, such as antiviral, antiproliferative and immunomodulatory activity in sensitive cells. Activation of the IFN-gamma receptor (IFN-γR) leads to autophosphorylation of the Janus kinases JAK1 and JAK2, and the nuclear translocation of the transcription factors Stat1α p91 and Stat1β p84. The IFN-γR is composed of at least two chains, designated IFN-γRα and IFN-γRβ, respectively. Although expression of IFN-γRα is sufficient for ligand binding, it alone does not confer responsiveness to IFN-γ. Concomitant expression of IFN-γRα and IFN-γRβ is required for transcriptional activation of IFN-γ-inducible genes. The IFN-γRβ chain, also called AF-1, is 332 and 337 amino acids in length in mouse and human, respectively, and may represent the signal transducing component of the IFN-γR.