mouse monoclonal IgG1; Mcl-1 Antibody (22) is an IgG1 κ mouse monoclonal Mcl-1 antibody (also designated MCL1 or Myeloid cell leukemia-1 antibody) that detects the Mcl-1 protein of human origin by WB, IP and ELISA. Mcl-1 Antibody (22) is available as both the non-conjugated anti-Mcl-1 antibody form, as well as multiple conjugated forms of anti-Mcl-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. B-cell CLL/lymphoma 2 (Bcl-2) blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal. Myeloid cell leukemia 1 (Mcl-1) shares sequence homology with Bcl-2 and further resembles Bcl-2 in that its expression promotes cell viability. p53 and Mcl-1 demonstrate opposing effects on mitochondrial apoptosis by mediating Bcl-2 antagonist killer (Bak) activity. Mcl-1 is an important and specific regulator that is necessary for the homeostasis of early hematopoietic progenitors. Glycogen synthase kinase 3 (GSK3) controls Mcl-1 stability, which has an effect on the regulation of apoptosis by growth factors, PI 3-kinase and AKT. Mice with a deficiency of the Mcl-1 protein show a significant reduction in B and T lymphocytes similar to the effects observed in IL-7- or IL-7R-deficient mice.