mouse monoclonal IgG2a; HSP 90α/β Antibody (F-8) is an IgG2a κ mouse monoclonal HSP 90 alpha / beta antibody (also designated HSP90 antibody, HSP90AA1 antibody or HSP90AB1 antibody) that detects the HSP 90 alpha / beta protein of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA. HSP 90α/β Antibody (F-8) is available as both the non-conjugated anti-HSP 90 alpha / beta antibody form, as well as multiple conjugated forms of anti-HSP 90 alpha / beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The heat shock response was first described for Drosophila salivary gland cells and morphologically consists of a change in their polytene chromosome puffing patterns that involves de novo synthesis of a few proteins. Similar heat shock proteins were later discovered in bacterial chicken and mammalian cells, and have been subsequently studied in other organisms. A series of proteins including HSP 90, HSP 70, HSP 20-30 and ubiquitin are induced by insults such as temperature shock, chemicals and other environmental stress. A major function of HSP 90 and other HSPs is to act as molecular chaperones. HSP 90 forms a complex with glucocorticoid receptor (GR), rendering the non ligand-bound receptor transcriptionally inactive. HSP 90 binds the GR as a heterocomplex composed of either HSP 56 or Cyclophilin D, forming an aporeceptor comiplex. HSP 90 also exists as a dimer with other proteins such as p60/sti1 and p23, forming an apo-receptor complex with estrogen and androgen receptors.