mouse monoclonal IgG2b; Cdk9 Antibody (D-7) is an IgG2b κ mouse monoclonal Cdk9 antibody (also designated Cyclin-dependent kinase 9 antibody, Serine/threonine-protein kinase PITALRE antibody or CDC2L4 antibody) that detects the Cdk9 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Cdk9 Antibody (D-7) is available as both the non-conjugated anti-Cdk9 antibody form, as well as multiple conjugated forms of anti-Cdk9 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. A family of proteins designated cyclin dependent kinases (Cdks) are critical regulators of cell cycle progression. Cdk family members, including Cdc2 p34, Cdk1-9, PISSLRE, KKIALRE, PITSLRE and PCTAIRE 1-3 are constitutively expressed throughout the cell cycle. Cdc2 p34 activity peaks during mitosis and Cdk2 activity rises in late G1 or early S phase. Cdk4 and Cdk6 are critically involved in G1 to S phase progression. The functions of Cdk3, Cdk5b, PISSLRE, KKIALRE and PCTAIRE 1-3 are less well defined. Cdk9 (also designated PITALRE) has been shown to specifically phosphorylate the retinoblastoma protein. The more recently cloned Drosophila protein, P-TEFb, is thought to be the homolog of mammalian PITALRE. P-TEFb has been shown to be required for HIV Tat transcriptional activation.