mouse monoclonal IgG1; PITPα Antibody (5F12) is an IgG1 κ mouse monoclonal PITP alpha antibody (also designated PITPα antibody) that detects the PITP alpha protein of mouse, rat and human origin by WB, IP and IF. PITPα Antibody (5F12) is available as both the non-conjugated anti-PITP alpha antibody form, as well as multiple conjugated forms of anti-PITP alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The lipid binding proteins known as phosphatidylinositol transfer proteins (PITP) facilitate the formation of phosphatidylinositol derived second messenger molecules, which are related to the phospholipase C and phosphoinositide 3-kinase pathways. PITP are ubiquitously expressed proteins that transfer phosphatidylinositol (PI) and phosphatidylcholine (PC) between membranes enriched in PI or PC to membranes that are deficient in PI or PC. PITP mobilizes PI from the endoplasmic recticulum and regulates the release of PI from stored vesicles in the Golgi network. In mammalian cells, three smaller forms of soluble PITP are present, designated PITP alpha, beta and retinal degeneration B (rdgB) beta. The gene encoding human rdgB beta maps to chromosome 11q13, a region that contains several retinopathy loci, which makes the H-rdgB beta gene a candidate for several inherited retinal degenerative diseases.