Santa Cruz Biotechnology

MMP-2 (8B4) | Santa Cruz Biotechnology

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mouse monoclonal IgG1; MMP-2 Antibody (8B4) is an IgG1 κ mouse monoclonal MMP-2 antibody that detects MMP-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. MMP-2 Antibody (8B4) is available as the non-conjugated anti-MMP-2 antibody form, as well as multiple conjugated forms of anti-MMP-2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.

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Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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