mouse monoclonal IgG1; PP2A-Aα/β Antibody (4G7) is an IgG1 κ mouse monoclonal PP2A-A alpha / beta antibody (also designated Serine/Threonine phosphatase PP2AA/PP2AB antibody, PR65A/PR65B antibody, protein phosphatase 2 subunit A (PP2A) alpha/beta antibody, PPP2R1A antibody, PPP2R1B antibody, PP2A 65 kDa subunit A alpha/beta antibody, PP2A heterotrimeric (structural A, regulatory B, catalytic C) protein phosphatase antibody, PP2A phosphatase scaffold A alpha/beta antibody, PP2A phosphatase structural A alpha/beta antibody, or Ser/Thr phosphatase antibody) that detects the PP2A-A alpha / beta protein of mouse, rat and human origin by WB, IP, IF and IHC(P). PP2A-Aα/β Antibody (4G7) is available as both the non-conjugated anti-PP2A-A alpha / beta antibody form, as well as multiple conjugated forms of anti-PP2A-A alpha / beta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aα and PP2Aβ. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-Aα and -Aβ, PP2A-Bα and -Bβ, PP2A-Cα and -Cβ and PP2A-B56α and -B56β.