mouse monoclonal IgG1; MEF-2A Antibody (B-4) is an IgG1 κ mouse monoclonal MEF-2A antibody (also designated MEF2A antibody, or myocyte enhancer factor 2A antibody) that detects the MEF-2A protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. MEF-2A Antibody (B-4) is available as both the non-conjugated anti-MEF-2A antibody form, as well as multiple conjugated forms of anti-MEF-2A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The myocyte enhancer factor-2 (MEF-2) family of transcription factors associate with co-repessors or co-activators to regulate development and function of T cells, neuronal cells, and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C, and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each duing embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including MyoD, myogenin, Myf-5, and MRF4, are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF-2) family. Each of these proteins binds to the MEF-2 target DNA sequence present in the regulatory regions of many muscle-specific genes.