mouse monoclonal IgG1; TGIF Antibody (H-1) is an IgG1 mouse monoclonal TGIF antibody (also designated TGFB Induced Factor Homeobox 1 antibody, 5'-TG-3'-Interacting Factor 1 antibody, Homeobox Protein TGIF1 antibody, TGIF antibody, Transforming Growth Factor-Beta-Induced Factor antibody, or TGFB-Induced Factor (TALE Family Homeobox) antibody) that detects the TGIF protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. TGIF Antibody (H-1) is available as both the non-conjugated anti-TGIF antibody form, as well as multiple conjugated forms of anti-TGIF antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TGIF (5′-TG-3′ interacting factor) was originally identified as a homeo-domain protein that binds to a retinoid X receptor (RXR) responsive element, thereby inhibiting the binding of RXR to this site and repressing RXR-dependent transcriptional activation. TGIF is a member of the TALE (three amino acid loop extension) family of homeodomain-containing proteins. TGIF also binds to Smad2, to repress Smad2-Smad4-mediated transcription. Smad2, after phosphorylation mediated by TGFβ receptor, forms a complex with Smad4 and enters the nucleus to regulate transcription. The Smad2-Smad4 complex can interact with coactivators to form a transcriptional activation complex. Alternatively, the Smad2-Smad4 complex can interact with TGIF and HDACs to form a transcriptional repressor complex. Upon interaction with Smad2, TGIF is recruited to TGFβ-responsive genes, where it acts to repress TGFβ-induced transcription.