mouse monoclonal IgG1; Arnt 1 Antibody (A-3) is an IgG1 κ mouse monoclonal Arnt 1 antibody (also designated ARNT antibody, HIF-1 beta antibody, HIF-1β antibody or Dioxin receptor, nuclear translocator antibody) that detects the Arnt 1 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Arnt 1 Antibody (A-3) is available as both the non-conjugated anti-Arnt 1 antibody form, as well as multiple conjugated forms of anti-Arnt 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. AhR, Arnt 1, Arnt 2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. Arnt 1 (aryl hydrocarbon receptor nuclear translocator), also known as HIF1B, TANGO, bHLHe2, HIF1BETA, HIF-1beta or ARNT, is a 789 amino acid nuclear protein that contains a basic helix-loop-helix (bHLH) domain, a PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains.