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Santa Cruz Biotechnology

TID-1L/S (RS-11) | Santa Cruz Biotechnology

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mouse monoclonal IgG1; TID-1 is the human homologue of the Drosophila tumor suppressor protein TID56. Both TID56 and TID-1 belong to the DnaJ family of proteins, which are characterized by a highly conserved J domain that influences apoptotic activity. The human TID-1 gene encodes two splice variants, TID-1L and TID-1S TID-1L expression increases apoptosis, whereas a mutant J domain suppresses apoptosis. By contrast, TID-1S expression suppresses apoptosis, whereas a mutant J domain increases apoptosis. TID-1L and TID-1S are localized to the mitochondrial matrix, where they regulate apoptotic signal transduction by affecting cytochrome c release and caspase-3 activation. Both TID-1L and TID-1S are cleaved at amino acid 66 upon entry into the mitochondria, indicating that mature TID-1L and TID-1S represent cleavage products of cytoplasmic pre-proteins.

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Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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