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Santa Cruz Biotechnology

group V PLA2 (3G1) PE | Santa Cruz Biotechnology

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mouse monoclonal IgG1; Phospholipase A2s (PLA2s) constitute a family of esterases that hydrolyze the sn-2-acyl ester bond in glycerophospholipid molecules. These enzymes are generally calcium-dependent and have been found both intra- and extracellularly. By hydrolyzing the sn-2 bond in glycerophospholipids, PLA2s release fatty acids. One such fatty acid, arachidonic acid, generates the substrates for the initiation of the arachidonic acid cascade that produces various eicosanoids (i.e., prostaglandins, leukotrienes and thromboxanes), many of which are potent mediators of inflammation. PLA2s include both the relatively low molecular weight group I, group II and group V enzymes and the form known as cytoplasmic PLA2 (cPLA2). cPLA2 is present in macrophages, and hydrolyzes the sn-2 fatty acyl ester bond of phospholipids to produce a free fatty acid and a lysophospholid.

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Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

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