mouse monoclonal IgG1; CDSN Antibody (C-3) is an IgG1 κ mouse monoclonal CDSN antibody (also designated CDSN antibody) that detects the CDSN protein of mouse, rat and human origin by WB, IP, IF and ELISA. CDSN Antibody (C-3) is available as both the non-conjugated anti-CDSN antibody form, as well as multiple conjugated forms of anti-CDSN antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Corneodesmosin (CDSN), also designated S protein, is a secreted protein found in corneodesmosomes, the intercellular structures that are involved in desquamation and the shedding of superficial corneocytes from the skin surface. CDSN expression is only observed in skin and its expression is associated with susceptibility to psoriasis, a heterogeneous inflammatory skin disease. The gene encoding for corneodesmosin, CDSN, is a strong candidate gene for psoriasis susceptibility due to its exclusive expression in differentiating keratinocytes. The CDSN gene contains 2 exons which encode a presumed 486-amino acid protein, including a putative 16-amino acid signal sequence. The CDSN protein shows homology to Loricrin, Cytokeratin 1 and Cytokeratin 10, which are all major components of the granular layer.