Companies / Santa Cruz Biotechnology / Cytokeratin 5/8 (C50) Alexa Fluor® 488
Santa Cruz Biotechnology

Cytokeratin 5/8 (C50) Alexa Fluor® 488 | Santa Cruz Biotechnology

(0) Write Review

mouse monoclonal IgG1; Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratin 5 is expressed in normal basal cells. Mutations of the cytokeratin 5 gene (KRT5) have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB). Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors Cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas.

Learn More

Reviews

(0) | Be the first to review this product
No reviews yet

ABOUT THE COMPANY

Santa Cruz Biotechnology

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.

Scientific Products
  • See More
    • Upcoming Virtual Events
    Upcoming Webinars