mouse monoclonal IgG2a; Dvl-1 Antibody (3F12) is an IgG2a κ mouse monoclonal Dvl-1 antibody (also designated DVL1 antibody, or dishevelled segment polarity protein 1 antibody) that detects the Dvl-1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Dvl-1 Antibody (3F12) is available as both the non-conjugated anti-Dvl-1 antibody form, as well as multiple conjugated forms of anti-Dvl-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be involved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3β. This finding may prove to be important in Alzheimer's studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.