mouse monoclonal IgG1; Bad Antibody (C-7) is an IgG1 κ mouse monoclonal Bad antibody (also designated BCL2 associated agonist of cell death antibody) that detects the Bad protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Bad Antibody (C-7) is available as both the non-conjugated anti-Bad antibody form, as well as multiple conjugated forms of anti-Bad antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL: Bax complexes thereby causing restoration of Bax-mediated apoptosis.