mouse monoclonal IgG1; Jun B Antibody (C-11) is an IgG1 κ mouse monoclonal Jun B antibody that detects the Jun B protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Jun B Antibody (C-11) is available as both the non-conjugated anti-Jun B antibody form, as well as multiple conjugated forms of anti-Jun B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.