mouse monoclonal IgG1; Met Antibody (B-2) is an IgG1 κ mouse monoclonal Met antibody (also designated c-Met antibody, HGFR antibody, AUTS9 antibody or RCCP2 antibody) that detects the Met protein of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA. Met Antibody (B-2) is available as both the non-conjugated anti-Met antibody form, as well as multiple conjugated forms of anti-Met antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a transmembrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. A high proportion of spontaneous NIH/3T3 transformants overexpress c-Met and by transfection analysis the c-Met proto-oncogene has been shown to exhibit transforming activity. Tyrosine phosphorylation of apparently normal Met protein has also been observed in certain human gastric carcinoma cell lines. The c-Met gene product has been identified as the cell-surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.