mouse monoclonal IgG1; Cytokeratin 7/17 (also designated KRT7 antibody, Keratin 7 antibody, KRT17 antibody, Keratin 17 antibody) comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas. Cytokeratin 7 is expressed in pancreatic duct cells and islets of Langerhans and is a marker for pancreatic duct cell differentiation. Cytokeratin 17 is normally expressed in complex epithelia basal cells and can be used as a marker for basal cell differentiation.