mouse monoclonal IgG1; 4E-BP1 Antibody (P-1) is an IgG1 κ mouse monoclonal 4E-BP1 antibody (also designated 4EBP1 antibody, EIF4EBP1 antibody, or eukaryotic translation initiation factor 4E binding protein 1 antibody) that detects the 4E-BP1 protein of mouse, rat, human and porcine origin by WB, IP, IF, IHC(P) and ELISA. 4E-BP1 Antibody (P-1) is available as both the non-conjugated anti-4E-BP1 antibody form, as well as multiple conjugated forms of anti-4E-BP1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The translation of proteins from eukaryotic mRNA is initiated by the multisubunit complex eIF-4F, which associates with the mRNA 5' cap structure. eIF-4E, a component of eIF-4F, is responsible for binding to the 5' cap structure and for the assembly of the eIF-4F complex. The regulatory protein 4E-BP1, also referred to as PHAS-I, inhibits eIF-4E function. Phosphorylation of 4E-BP1 by S6 kinase p70, MAP kinases or PKCs causes the disassociation of 4E-BP1 from eIF-4E, promoting translation. A protein that is functionally related to 4E-BP1, designated 4E-BP2, also associates with eIF-4E.